Assay Detail
Binding
CHEMBL701163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human immunodeficiency virus-1 (HIV-1) integrase.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.91 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37869 | — | — | 1 | 6.52 |
| CHEMBL39092 | — | — | 1 | 5.62 |
| CHEMBL36586 | — | — | 1 | 5.60 |
| CHEMBL293788 | — | — | 1 | - |
| CHEMBL418303 | — | — | 1 | - |
| CHEMBL58191 | — | — | 1 | - |
| CHEMBL61800 | — | — | 1 | - |
| CHEMBL58923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37869 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL39092 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL36586 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL293788 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61800 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58923 | — | IC50 | > | 100000.0 | nM | - |