Assay Detail
Functional
CHEMBL701194
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Inhibition of murine L1210 cell line tissue culture growth
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.52 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.35 |
| CHEMBL171706 | — | — | 1 | 6.18 |
| CHEMBL417222 | — | — | 1 | 6.07 |
| CHEMBL422395 | — | — | 1 | 5.80 |
| CHEMBL162754 | — | — | 1 | 5.77 |
| CHEMBL172085 | — | — | 1 | 5.75 |
| CHEMBL291548 | — | — | 1 | 5.70 |
| CHEMBL170177 | — | — | 1 | 5.56 |
| CHEMBL172474 | — | — | 1 | 5.55 |
| CHEMBL170573 | — | — | 1 | 5.51 |
| CHEMBL172033 | — | — | 1 | 5.47 |
| CHEMBL353951 | — | — | 1 | 5.35 |
| CHEMBL367651 | — | — | 1 | 5.33 |
| CHEMBL171549 | — | — | 1 | 5.30 |
| CHEMBL171180 | — | — | 1 | 5.30 |
| CHEMBL171418 | — | — | 1 | 5.11 |
| CHEMBL170527 | — | — | 1 | 4.83 |
| CHEMBL173683 | — | — | 1 | 4.70 |
| CHEMBL355011 | — | — | 1 | 4.32 |
| CHEMBL301423 | — | — | 1 | - |
| CHEMBL171641 | — | — | 1 | - |
| CHEMBL444870 | — | — | 1 | - |
| CHEMBL170204 | — | — | 1 | - |
| CHEMBL57333 | — | — | 1 | - |
| CHEMBL171754 | — | — | 1 | - |
| CHEMBL422735 | — | — | 1 | - |
| CHEMBL174478 | — | — | 1 | - |
| CHEMBL170626 | — | — | 1 | - |
| CHEMBL170767 | — | — | 1 | - |
| CHEMBL433923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL171706 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL417222 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL422395 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL162754 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL172085 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL291548 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL170177 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL172474 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL170573 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL172033 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL353951 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL367651 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL171549 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL171180 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL171418 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL170527 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL173683 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL355011 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL301423 | — | IC50 | > | 2200.0 | nM | - |
| CHEMBL171641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL444870 | — | IC50 | > | 2800.0 | nM | - |
| CHEMBL170204 | — | IC50 | > | 5300.0 | nM | - |
| CHEMBL57333 | — | IC50 | > | 6500.0 | nM | - |
| CHEMBL171754 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL422735 | — | IC50 | > | 2400.0 | nM | - |
| CHEMBL174478 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL170626 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL170767 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL433923 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL171189 | — | IC50 | > | 49000.0 | nM | - |
| CHEMBL177208 | — | IC50 | > | 5600.0 | nM | - |