Assay Detail
Functional
CHEMBL701250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity on sorbital accumulation in human retinal cells was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.74 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.70 |
| CHEMBL150198 | — | — | 1 | 6.62 |
| CHEMBL151952 | — | — | 1 | 6.00 |
| CHEMBL150098 | — | — | 1 | 5.52 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.40 |
| CHEMBL148918 | — | — | 1 | 5.22 |
| CHEMBL357100 | — | — | 1 | 5.16 |
| CHEMBL148864 | — | — | 1 | 5.10 |
| CHEMBL414496 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL150198 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL151952 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL150098 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL266497 | SORBINIL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL148918 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL357100 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL148864 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL414496 | — | IC50 | = | 11000.0 | nM | 4.96 |