Assay Detail
Binding
CHEMBL701283
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Inhibitory activity against HIV-1 Integrase in strand transfer (integration)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.59 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39481 | — | — | 1 | 5.92 |
| CHEMBL39301 | — | — | 1 | 5.92 |
| CHEMBL418613 | — | — | 1 | 5.80 |
| CHEMBL431508 | — | — | 1 | 5.77 |
| CHEMBL40148 | — | — | 1 | 5.68 |
| CHEMBL39883 | — | — | 1 | 5.66 |
| CHEMBL287903 | — | — | 1 | 5.52 |
| CHEMBL37139 | — | — | 1 | 5.48 |
| CHEMBL40170 | — | — | 1 | 5.43 |
| CHEMBL37431 | — | — | 1 | 5.35 |
| CHEMBL39143 | — | — | 1 | 4.96 |
| CHEMBL39823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39481 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL39301 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL418613 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL431508 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL40148 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL39883 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL287903 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL37139 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL40170 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL37431 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL39143 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL39823 | — | IC50 | > | 100000.0 | nM | - |