Assay Detail
Binding
CHEMBL701348
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Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (CHEMBL3904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.08 | 8.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297496 | — | — | 1 | 8.93 |
| CHEMBL46273 | — | — | 1 | 6.73 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 6.71 |
| CHEMBL297235 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297496 | — | Kd | = | 1.17 | nM | 8.93 |
| CHEMBL46273 | — | Kd | = | 188.0 | nM | 6.73 |
| CHEMBL279107 | INS(1,4,5)P3 | Kd | = | 195.0 | nM | 6.71 |
| CHEMBL297235 | — | Kd | = | 1116.0 | nM | 5.95 |