Assay Detail
Binding
CHEMBL701376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]diltiazem binding to L-type calcium channels of rabbit skeletal muscle
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.04 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345520 | — | — | 1 | 6.96 |
| CHEMBL358173 | — | — | 1 | 6.70 |
| CHEMBL347891 | — | — | 1 | 6.68 |
| CHEMBL16192 | CP-96345 | — | 1 | 6.62 |
| CHEMBL434272 | — | — | 1 | 6.33 |
| CHEMBL154803 | — | — | 1 | 6.09 |
| CHEMBL348594 | — | — | 1 | 5.57 |
| CHEMBL345866 | — | — | 1 | 5.43 |
| CHEMBL153976 | — | — | 1 | 5.25 |
| CHEMBL349113 | — | — | 1 | 4.79 |
| CHEMBL155976 | — | — | 1 | - |
| CHEMBL156933 | — | — | 1 | - |
| CHEMBL357757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345520 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL358173 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL347891 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL16192 | CP-96345 | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL434272 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL154803 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL348594 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL345866 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL153976 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL349113 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL155976 | — | IC50 | >> | 5000.0 | nM | - |
| CHEMBL156933 | — | IC50 | >> | 5000.0 | nM | - |
| CHEMBL357757 | — | IC50 | > | 5000.0 | nM | - |