Assay Detail
Functional
CHEMBL701377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]diltiazem binding to L-type calcium channel of rabbit skeletal muscle
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Piperidine-ether based hNK1 antagonists 2: Investigation of the effect of N-substitution
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.37 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65153 | — | — | 1 | 8.39 |
| CHEMBL67612 | — | — | 1 | 7.58 |
| CHEMBL432279 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65153 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL67612 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL432279 | — | IC50 | = | 720.0 | nM | 6.14 |