Assay Detail
Functional
CHEMBL701391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to reduce proliferation of KB subclones passaged in the presence of doxorubicin 0.09 uM (KBMDR) cell line by 50% as determined by the MTT method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 6.70 |
| CHEMBL353101 | — | — | 1 | 6.52 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 6.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.75 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL353101 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL44657 | ETOPOSIDE | IC50 | > | 20000.0 | nM | - |