Assay Detail
Binding
CHEMBL701411
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Inhibition of human lck kinase.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.22 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47787 | — | — | 1 | 8.40 |
| CHEMBL43773 | — | — | 1 | 8.00 |
| CHEMBL416091 | — | — | 1 | 7.72 |
| CHEMBL295601 | — | — | 1 | 7.55 |
| CHEMBL295528 | — | — | 1 | 7.51 |
| CHEMBL46785 | — | — | 1 | 7.40 |
| CHEMBL45683 | — | — | 1 | 7.30 |
| CHEMBL417006 | — | — | 1 | 7.04 |
| CHEMBL297363 | — | — | 1 | 7.03 |
| CHEMBL45693 | — | — | 1 | 6.96 |
| CHEMBL46176 | — | — | 1 | 6.78 |
| CHEMBL45651 | — | — | 1 | 6.68 |
| CHEMBL402673 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47787 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL43773 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL416091 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL295601 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL295528 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL46785 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL45683 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL417006 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL297363 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL45693 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL46176 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL45651 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL402673 | — | IC50 | = | 3120.0 | nM | 5.51 |