Assay Detail
Functional
CHEMBL701563
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Compound was evaluated for cytotoxic activity against K562 human chronic myelogenous leukemia cell line using MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antimitotic and cell growth inhibitory properties of substituted chalcones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.45 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9859 | — | — | 1 | 9.68 |
| CHEMBL9941 | — | — | 1 | 8.37 |
| CHEMBL9652 | — | — | 1 | 7.96 |
| CHEMBL9926 | — | — | 1 | 7.92 |
| CHEMBL275735 | — | — | 1 | 7.85 |
| CHEMBL276828 | — | — | 1 | 7.44 |
| CHEMBL273256 | — | — | 1 | 7.10 |
| CHEMBL276600 | — | — | 1 | 6.52 |
| CHEMBL9184 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9859 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL9941 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL9652 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL9926 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL275735 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL276828 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL273256 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL276600 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL9184 | — | IC50 | = | 60000.0 | nM | 4.22 |