Assay Detail
Functional
CHEMBL701564
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Compound was evaluated for in vitro activity against K562 leukemia cell lines (Human tumor cells )
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.55 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 9.52 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.58 |
| CHEMBL150607 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL150607 | — | IC50 | < | 0.1 | nM | - |