Assay Detail
Functional
CHEMBL701574
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Antiproliferative activity measured against K562adr leukemia cells.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.31 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150850 | — | — | 1 | 8.59 |
| CHEMBL345989 | — | — | 1 | 8.54 |
| CHEMBL358471 | — | — | 1 | 7.85 |
| CHEMBL149851 | — | — | 1 | 7.75 |
| CHEMBL348711 | — | — | 1 | 7.70 |
| CHEMBL151419 | — | — | 1 | 7.48 |
| CHEMBL345998 | — | — | 1 | 7.43 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.24 |
| CHEMBL150195 | — | — | 1 | 7.20 |
| CHEMBL151912 | — | — | 1 | 7.18 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 5.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150850 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL345989 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL358471 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL149851 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL348711 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL151419 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL345998 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL150195 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL151912 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15000.0 | nM | 4.82 |