Assay Detail
Binding
CHEMBL701582
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Binding affinity against kallikrein
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.41 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3349045 | — | — | 1 | 8.21 |
| CHEMBL418050 | — | — | 1 | 8.02 |
| CHEMBL290577 | — | — | 1 | 8.02 |
| CHEMBL36744 | — | — | 1 | 7.47 |
| CHEMBL291026 | — | — | 1 | 6.92 |
| CHEMBL287918 | — | — | 1 | 6.80 |
| CHEMBL288176 | — | — | 1 | 6.43 |
| CHEMBL291261 | — | — | 1 | - |
| CHEMBL2448441 | — | — | 1 | - |
| CHEMBL285285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3349045 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL418050 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL290577 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL36744 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL291026 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL287918 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL288176 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL291261 | — | Ki | > | 63.0 | nM | - |
| CHEMBL2448441 | — | Ki | = | 0.0049 | nM | - |
| CHEMBL285285 | — | Ki | > | 4.3 | nM | - |