Assay Detail
Binding
CHEMBL701592
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Inhibitory activity against Kallikrein
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.95 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423810 | — | — | 1 | 8.03 |
| CHEMBL352039 | — | — | 1 | 7.57 |
| CHEMBL350587 | — | — | 1 | 7.47 |
| CHEMBL355376 | — | — | 1 | 6.62 |
| CHEMBL163174 | — | — | 1 | 6.41 |
| CHEMBL159695 | — | — | 1 | 6.39 |
| CHEMBL162461 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423810 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL352039 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL350587 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL355376 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL163174 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL159695 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL162461 | — | IC50 | = | 677.0 | nM | 6.17 |