Assay Detail
Functional
CHEMBL701696
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In vitro inhibitory activity against K562 human leukemia cell line
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.44 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344918 | — | — | 1 | 6.16 |
| CHEMBL136356 | HELENINE | — | 1 | 6.16 |
| CHEMBL137803 | ISOALANTOLACTONE | — | 1 | 5.92 |
| CHEMBL137440 | — | — | 1 | 5.70 |
| CHEMBL434233 | — | — | 1 | 5.70 |
| CHEMBL342639 | — | — | 1 | 5.70 |
| CHEMBL337106 | — | — | 1 | 5.52 |
| CHEMBL137441 | — | — | 1 | 5.52 |
| CHEMBL135257 | — | — | 1 | 5.40 |
| CHEMBL135368 | — | — | 1 | 5.30 |
| CHEMBL137242 | — | — | 1 | 5.30 |
| CHEMBL136134 | — | — | 1 | 5.30 |
| CHEMBL138644 | — | — | 1 | 5.30 |
| CHEMBL342265 | — | — | 1 | 5.22 |
| CHEMBL337569 | — | — | 1 | 4.82 |
| CHEMBL422812 | — | — | 1 | 4.82 |
| CHEMBL335608 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344918 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL136356 | HELENINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL137803 | ISOALANTOLACTONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL137440 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL434233 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL342639 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL337106 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL137441 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL135257 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL135368 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL137242 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL136134 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL138644 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL342265 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL337569 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL422812 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL335608 | — | IC50 | = | 24000.0 | nM | 4.62 |