Assay Detail
Binding
CHEMBL701716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect on strand transfer of proximal DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348565 | — | — | 1 | 5.72 |
| CHEMBL22197 | — | — | 1 | 5.70 |
| CHEMBL108423 | — | — | 1 | 5.11 |
| CHEMBL16326 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348565 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL22197 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL108423 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL16326 | — | IC50 | = | 24200.0 | nM | 4.62 |