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Assay Detail

CHEMBL701724

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Binding
In vitro inhibitory activity against HIV-1 integrase.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 integrase (CHEMBL3471)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Hydroxylated aromatic inhibitors of HIV-1 integrase.
Burke TR, Fesen MR, Mazumder A, Wang J, Carothers AM, Grunberger D, Driscoll J, Kohn K, Pommier Y.
J Med Chem (1995) 38 : 4171 -4178
PubMed 7473544 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 4.80 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL131733 1 5.70
CHEMBL132058 1 5.70
CHEMBL18266 1 5.52
CHEMBL131904 1 5.40
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER 1 5.16
CHEMBL18276 1 5.10
CHEMBL131982 1 5.10
CHEMBL133714 BENZYL CAFFEATE 1 5.05
CHEMBL133992 1 4.96
CHEMBL413118 1 4.85
CHEMBL133491 1 4.82
CHEMBL132238 1 4.75
CHEMBL49350 1 4.40
CHEMBL133492 1 4.36
CHEMBL132379 1 4.32
CHEMBL131749 1 4.26
CHEMBL131680 1 4.22
CHEMBL131689 1 4.17
CHEMBL48436 1 4.12
CHEMBL133937 1 4.03
CHEMBL296582 1 -
CHEMBL296407 1 -
CHEMBL17347 ETHYL CAFFEATE 1 -
CHEMBL132024 1 -
CHEMBL442022 1 -
CHEMBL337498 1 -
CHEMBL133828 1 -
CHEMBL132194 1 -
CHEMBL133642 1 -
CHEMBL131678 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL131733 IC50 = 2000.0 nM 5.70
CHEMBL132058 IC50 = 2000.0 nM 5.70
CHEMBL18266 IC50 = 3000.0 nM 5.52
CHEMBL131904 IC50 = 4000.0 nM 5.40
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER IC50 = 7000.0 nM 5.16
CHEMBL18276 IC50 = 8000.0 nM 5.10
CHEMBL131982 IC50 = 8000.0 nM 5.10
CHEMBL133714 BENZYL CAFFEATE IC50 = 9000.0 nM 5.05
CHEMBL133992 IC50 = 11000.0 nM 4.96
CHEMBL413118 IC50 = 14000.0 nM 4.85
CHEMBL133491 IC50 = 15000.0 nM 4.82
CHEMBL132238 IC50 = 18000.0 nM 4.75
CHEMBL49350 IC50 = 40000.0 nM 4.40
CHEMBL133492 IC50 = 44000.0 nM 4.36
CHEMBL132379 IC50 = 48000.0 nM 4.32
CHEMBL131749 IC50 = 55000.0 nM 4.26
CHEMBL131680 IC50 = 60000.0 nM 4.22
CHEMBL131689 IC50 = 68000.0 nM 4.17
CHEMBL48436 IC50 = 75000.0 nM 4.12
CHEMBL133937 IC50 = 93000.0 nM 4.03
CHEMBL296582 IC50 > 100000.0 nM -
CHEMBL296407 IC50 > 100000.0 nM -
CHEMBL17347 ETHYL CAFFEATE IC50 > 100000.0 nM -
CHEMBL132024 IC50 > 100000.0 nM -
CHEMBL442022 IC50 > 100000.0 nM -
CHEMBL337498 IC50 > 100000.0 nM -
CHEMBL133828 IC50 > 100000.0 nM -
CHEMBL132194 IC50 > 100000.0 nM -
CHEMBL133642 IC50 > 100000.0 nM -
CHEMBL131678 IC50 > 100000.0 nM -
CHEMBL17001 METHYLCAFFEATE IC50 > 100000.0 nM -
CHEMBL134573 IC50 > 100000.0 nM -