Assay Detail
Binding
CHEMBL701725
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Inhibitory activity against Human Immunodeficiency Virus Type 1 integrase (HIV-1 IN) in the disintegration assay.
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.05 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29660 | CHICORIC ACID | — | 1 | 7.16 |
| CHEMBL63592 | — | — | 2 | 7.10 |
| CHEMBL415678 | — | — | 1 | 6.37 |
| CHEMBL30868 | — | — | 1 | 6.28 |
| CHEMBL149674 | — | — | 1 | 6.22 |
| CHEMBL149893 | — | — | 1 | 6.10 |
| CHEMBL148364 | — | — | 1 | 6.06 |
| CHEMBL357646 | — | — | 1 | 6.01 |
| CHEMBL146489 | — | — | 1 | 6.00 |
| CHEMBL149826 | — | — | 1 | 5.99 |
| CHEMBL357831 | — | — | 1 | 5.97 |
| CHEMBL249447 | — | — | 1 | 5.89 |
| CHEMBL358821 | — | — | 1 | 5.85 |
| CHEMBL487258 | CYNARIN | — | 1 | 5.80 |
| CHEMBL440354 | — | — | 1 | 5.79 |
| CHEMBL149178 | — | — | 1 | 5.75 |
| CHEMBL149475 | — | — | 1 | 5.62 |
| CHEMBL146179 | — | — | 1 | 5.16 |
| CHEMBL149305 | — | — | 1 | 5.08 |
| CHEMBL348709 | — | — | 1 | - |
| CHEMBL31026 | — | — | 1 | - |
| CHEMBL286477 | — | — | 1 | - |
| CHEMBL149306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29660 | CHICORIC ACID | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL63592 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL63592 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL415678 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL30868 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL149674 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL149893 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL148364 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL357646 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL146489 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL149826 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL357831 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL249447 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL358821 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL487258 | CYNARIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL440354 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL149178 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL149475 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL146179 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL149305 | — | IC50 | = | 8360.0 | nM | 5.08 |
| CHEMBL31026 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL348709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL286477 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL149306 | — | IC50 | > | 10000.0 | nM | - |