Assay Detail
Binding
CHEMBL701726
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Inhibitory activity against integrase as yield of terminal cleavage products
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.60 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301410 | — | — | 2 | 4.85 |
| CHEMBL430776 | — | — | 2 | 4.80 |
| CHEMBL301226 | — | — | 2 | 4.75 |
| CHEMBL57138 | — | — | 2 | 4.62 |
| CHEMBL56784 | — | — | 2 | 4.60 |
| CHEMBL297923 | — | — | 2 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301410 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL430776 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL301226 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL301410 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL301226 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL430776 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL57138 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL56784 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL57138 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL56784 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL297923 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL297923 | — | IC50 | = | 73000.0 | nM | 4.14 |