Assay Detail
Binding
CHEMBL701793
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Inhibitory concentration of compound against disintegration (reversal of strand transfer)of HIV-1 integrase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.60 | 4.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173530 | STICTIC ACID | — | 1 | 4.93 |
| CHEMBL285415 | — | — | 1 | 4.89 |
| CHEMBL177021 | — | — | 1 | 4.58 |
| CHEMBL171637 | PHYSODIC ACID | — | 1 | 4.49 |
| CHEMBL366410 | — | — | 1 | 4.47 |
| CHEMBL171896 | — | — | 1 | 4.46 |
| CHEMBL172018 | — | — | 1 | 4.41 |
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173530 | STICTIC ACID | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL285415 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL177021 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL171637 | PHYSODIC ACID | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL366410 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL171896 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL172018 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL367881 | (+)-USNIC ACID | IC50 | = | 133000.0 | nM | - |