Assay Detail
Binding
CHEMBL701838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound for depolarization induced by 5 uM S-AMPA in mouse cortical wedge preparation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.27 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 6.70 |
| CHEMBL310286 | — | — | 1 | 5.34 |
| CHEMBL432748 | — | — | 1 | 4.54 |
| CHEMBL307267 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL310286 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL432748 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL307267 | — | Ki | = | 33000.0 | nM | 4.48 |