Assay Detail
Functional
CHEMBL701854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of L1210 cell growth in culture.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.85 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44564 | — | — | 1 | 8.22 |
| CHEMBL290718 | — | — | 1 | 8.15 |
| CHEMBL42626 | — | — | 1 | 8.10 |
| CHEMBL43080 | — | — | 1 | 8.10 |
| CHEMBL41927 | — | — | 1 | 7.89 |
| CHEMBL289697 | — | — | 1 | 7.80 |
| CHEMBL40851 | — | — | 1 | 7.80 |
| CHEMBL290469 | — | — | 1 | 7.70 |
| CHEMBL41225 | — | — | 1 | 7.70 |
| CHEMBL40877 | — | — | 1 | 7.24 |
| CHEMBL40591 | — | — | 1 | 7.22 |
| CHEMBL418433 | — | — | 1 | 7.22 |
| CHEMBL291075 | — | — | 1 | 7.22 |
| CHEMBL44242 | — | — | 1 | 7.00 |
| CHEMBL42315 | — | — | 1 | 7.00 |
| CHEMBL40663 | — | — | 1 | 7.00 |
| CHEMBL42357 | — | — | 1 | 6.96 |
| CHEMBL41445 | — | — | 1 | 6.89 |
| CHEMBL41609 | — | — | 1 | 6.85 |
| CHEMBL295866 | — | — | 1 | 6.80 |
| CHEMBL44127 | — | — | 1 | 6.70 |
| CHEMBL42865 | — | — | 1 | 6.55 |
| CHEMBL40539 | — | — | 1 | 6.52 |
| CHEMBL44037 | — | — | 1 | 6.44 |
| CHEMBL288307 | — | — | 1 | 6.40 |
| CHEMBL43454 | — | — | 1 | 6.19 |
| CHEMBL539936 | — | — | 1 | 6.17 |
| CHEMBL41424 | — | — | 1 | 6.11 |
| CHEMBL410300 | — | — | 1 | 6.05 |
| CHEMBL40195 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44564 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL290718 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL42626 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL43080 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL41927 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL289697 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL40851 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL290469 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL41225 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL40877 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL40591 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL418433 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL291075 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL40663 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL42315 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL44242 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL42357 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL41445 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL41609 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL295866 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL44127 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL42865 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL40539 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL44037 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL288307 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL43454 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL539936 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL41424 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL410300 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL40195 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1788164 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL434973 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL435171 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL40739 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL40707 | — | IC50 | = | 3000.0 | nM | 5.52 |