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Assay Detail

CHEMBL701856

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cytotoxicity against L1210 (murine leukemia) cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological evaluation of N1-(anthracen-9-ylmethyl)triamines as molecular recognition elements for the polyamine transporter.
Wang C, Delcros JG, Biggerstaff J, Phanstiel O.
J Med Chem (2003) 46 : 2663 -2671
PubMed 12801230 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.33 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL540552 1 6.52
CHEMBL543610 1 6.40
CHEMBL545253 1 6.40
CHEMBL33920 1 6.22
CHEMBL544313 1 6.16
CHEMBL554675 1 5.89
CHEMBL539791 1 5.75
CHEMBL312821 1 5.48
CHEMBL33916 1 5.22
CHEMBL89548 1 5.21
CHEMBL422775 1 5.20
CHEMBL419683 1 5.13
CHEMBL92204 1 4.84
CHEMBL33912 1 4.55
CHEMBL441413 1 4.48
CHEMBL284260 1 4.26
CHEMBL30952 1 4.22
CHEMBL37716 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL540552 IC50 = 300.0 nM 6.52
CHEMBL543610 IC50 = 400.0 nM 6.40
CHEMBL545253 IC50 = 400.0 nM 6.40
CHEMBL33920 IC50 = 600.0 nM 6.22
CHEMBL544313 IC50 = 700.0 nM 6.16
CHEMBL554675 IC50 = 1300.0 nM 5.89
CHEMBL539791 IC50 = 1800.0 nM 5.75
CHEMBL312821 IC50 = 3300.0 nM 5.48
CHEMBL33916 IC50 = 6000.0 nM 5.22
CHEMBL89548 IC50 = 6200.0 nM 5.21
CHEMBL422775 IC50 = 6300.0 nM 5.20
CHEMBL419683 IC50 = 7400.0 nM 5.13
CHEMBL92204 IC50 = 14600.0 nM 4.84
CHEMBL33912 IC50 = 28000.0 nM 4.55
CHEMBL441413 IC50 = 33000.0 nM 4.48
CHEMBL284260 IC50 = 55000.0 nM 4.26
CHEMBL30952 IC50 = 60000.0 nM 4.22
CHEMBL37716 IC50 = 100000.0 nM 4.00