Assay Detail
Functional
CHEMBL701857
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Cytotoxicity was determined against alpha-difluoromethylornithine (DFMO) treated L1210 (murine leukemia) cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of N1-(anthracen-9-ylmethyl)triamines as molecular recognition elements for the polyamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.82 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540552 | — | — | 1 | 6.82 |
| CHEMBL543610 | — | — | 1 | 6.70 |
| CHEMBL545253 | — | — | 1 | 6.52 |
| CHEMBL544313 | — | — | 1 | 6.52 |
| CHEMBL554675 | — | — | 1 | 6.16 |
| CHEMBL539791 | — | — | 1 | 5.85 |
| CHEMBL312821 | — | — | 1 | 5.41 |
| CHEMBL89548 | — | — | 1 | 5.16 |
| CHEMBL422775 | — | — | 1 | 5.11 |
| CHEMBL419683 | — | — | 1 | 5.09 |
| CHEMBL92204 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540552 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL543610 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL545253 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL544313 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL554675 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL539791 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL312821 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL89548 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL422775 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL419683 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL92204 | — | IC50 | = | 21900.0 | nM | 4.66 |