Assay Detail
Binding
CHEMBL701899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.
21
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.47 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143614 | — | — | 2 | 7.00 |
| CHEMBL147317 | — | — | 1 | 6.85 |
| CHEMBL146777 | — | — | 1 | 6.82 |
| CHEMBL50605 | — | — | 1 | 6.77 |
| CHEMBL359212 | — | — | 1 | 6.75 |
| CHEMBL342295 | — | — | 1 | 6.66 |
| CHEMBL144727 | — | — | 1 | 6.60 |
| CHEMBL358506 | — | — | 1 | 6.30 |
| CHEMBL144118 | — | — | 2 | 6.30 |
| CHEMBL145946 | — | — | 2 | 6.30 |
| CHEMBL147209 | — | — | 1 | 5.25 |
| CHEMBL145280 | — | — | 1 | - |
| CHEMBL147147 | — | — | 1 | - |
| CHEMBL148241 | — | — | 1 | - |
| CHEMBL357909 | — | — | 1 | - |
| CHEMBL145705 | — | — | 1 | - |
| CHEMBL19464 | — | — | 1 | - |
| CHEMBL145335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143614 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147317 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL146777 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL143614 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL50605 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL359212 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL342295 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL144727 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL358506 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL144118 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL145946 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL145946 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL144118 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL147209 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL147147 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL145280 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL148241 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL357909 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL145705 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL19464 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL145335 | — | IC50 | < | 100.0 | nM | - |