Assay Detail
Functional
CHEMBL701906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against hepatitis B virus infected 2.2.15 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.52 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.85 |
| CHEMBL305612 | — | — | 1 | 5.70 |
| CHEMBL306257 | SYNGUANOL | — | 1 | 5.00 |
| CHEMBL75950 | — | — | 1 | - |
| CHEMBL75956 | — | — | 1 | - |
| CHEMBL76121 | — | — | 1 | - |
| CHEMBL74478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL305612 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL306257 | SYNGUANOL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL75950 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL75956 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL76121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL74478 | — | IC50 | > | 10000.0 | nM | - |