Assay Detail
Binding
CHEMBL701910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 5-alpha reductase-1 at a concentration of 5 microL after pre-incubation for 10 minutes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.86 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138173 | — | — | 1 | 8.16 |
| CHEMBL308258 | — | — | 1 | 8.09 |
| CHEMBL420020 | — | — | 1 | 8.05 |
| CHEMBL137733 | — | — | 1 | 7.96 |
| CHEMBL312531 | — | — | 1 | 7.85 |
| CHEMBL412425 | — | — | 1 | 7.70 |
| CHEMBL77328 | — | — | 1 | 7.70 |
| CHEMBL306722 | — | — | 1 | 7.70 |
| CHEMBL24088 | — | — | 1 | 7.52 |
| CHEMBL436215 | — | — | 1 | 7.12 |
| CHEMBL297524 | — | — | 1 | 6.82 |
| CHEMBL137691 | — | — | 1 | 6.72 |
| CHEMBL135780 | — | — | 1 | 6.44 |
| CHEMBL73816 | — | — | 1 | 6.24 |
| CHEMBL136863 | — | — | 1 | 6.14 |
| CHEMBL76648 | — | — | 1 | 6.12 |
| CHEMBL76192 | — | — | 1 | 6.09 |
| CHEMBL24291 | — | — | 1 | 5.66 |
| CHEMBL307626 | — | — | 1 | 5.64 |
| CHEMBL135313 | — | — | 1 | 5.22 |
| CHEMBL310710 | — | — | 1 | 5.07 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138173 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL308258 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL420020 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL137733 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL312531 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL412425 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL77328 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL306722 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL24088 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL436215 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL297524 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL137691 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL135780 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL73816 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL136863 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL76648 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL76192 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL24291 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL307626 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL135313 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL310710 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL138225 | EPRISTERIDE | Ki | > | 5000.0 | nM | - |