Assay Detail
Functional
CHEMBL701917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human whole blood LTB-4 production (Leukotriene B-4).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.52 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543405 | — | — | 1 | 7.31 |
| CHEMBL117132 | — | — | 1 | 7.26 |
| CHEMBL119683 | — | — | 1 | 7.16 |
| CHEMBL419220 | — | — | 1 | 7.14 |
| CHEMBL323686 | — | — | 1 | 7.12 |
| CHEMBL119814 | — | — | 1 | 7.12 |
| CHEMBL116571 | — | — | 1 | 7.02 |
| CHEMBL115857 | — | — | 1 | 6.96 |
| CHEMBL117654 | — | — | 1 | 6.96 |
| CHEMBL119545 | — | — | 1 | 6.92 |
| CHEMBL119612 | — | — | 1 | 6.72 |
| CHEMBL117833 | — | — | 1 | 6.72 |
| CHEMBL326601 | — | — | 1 | 6.72 |
| CHEMBL420866 | — | — | 1 | 6.72 |
| CHEMBL119529 | — | — | 1 | 6.68 |
| CHEMBL117148 | — | — | 1 | 6.64 |
| CHEMBL117549 | — | — | 1 | 6.64 |
| CHEMBL332556 | — | — | 1 | 6.60 |
| CHEMBL119179 | — | — | 1 | 6.55 |
| CHEMBL119124 | — | — | 1 | 6.52 |
| CHEMBL420502 | — | — | 1 | 6.46 |
| CHEMBL117314 | — | — | 1 | 6.38 |
| CHEMBL117256 | — | — | 1 | 6.35 |
| CHEMBL117455 | — | — | 1 | 6.35 |
| CHEMBL331917 | — | — | 1 | 6.34 |
| CHEMBL326507 | — | — | 1 | 6.31 |
| CHEMBL117231 | — | — | 1 | 6.28 |
| CHEMBL118014 | — | — | 1 | 6.25 |
| CHEMBL119240 | — | — | 1 | 6.23 |
| CHEMBL421048 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543405 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL117132 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL119683 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL419220 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL323686 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL119814 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL116571 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL115857 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL117654 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL119545 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL119612 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL420866 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL326601 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL117833 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL119529 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL117148 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL117549 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL332556 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL119179 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL119124 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL420502 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL117314 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL117256 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL117455 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL331917 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL326507 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL117231 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL118014 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL119240 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL421048 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL119054 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL323873 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL117472 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL119024 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL119422 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL325224 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL116908 | — | IC50 | > | 30000.0 | nM | - |