Assay Detail
Functional
CHEMBL701951
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Tested for the ability to inhibit growth in vitro against L1210
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.26 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136010 | — | — | 1 | 8.64 |
| CHEMBL337051 | — | — | 1 | 8.62 |
| CHEMBL341401 | — | — | 1 | 8.41 |
| CHEMBL132142 | — | — | 1 | 8.38 |
| CHEMBL335716 | — | — | 1 | 8.22 |
| CHEMBL134817 | — | — | 1 | 8.21 |
| CHEMBL132431 | — | — | 1 | 8.05 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.05 |
| CHEMBL134110 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136010 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL337051 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL341401 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL132142 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL335716 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL134817 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL132431 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL134110 | — | IC50 | = | 16.0 | nM | 7.80 |