Assay Detail
Functional
CHEMBL701980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose required to inhibit cell growth was determined against K562 cell line of chronic myelogenous leukemia
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antimitotic antitumor agents: synthesis, structure-activity relationships, and biological characterization of N-aryl-N'-(2-chloroethyl)ureas as new selective alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.02 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356033 | — | — | 1 | 5.89 |
| CHEMBL358165 | — | — | 1 | 5.89 |
| CHEMBL357489 | — | — | 1 | 5.68 |
| CHEMBL159697 | — | — | 1 | 5.60 |
| CHEMBL148690 | — | — | 1 | 5.52 |
| CHEMBL146303 | — | — | 1 | 5.46 |
| CHEMBL160114 | — | — | 1 | 5.46 |
| CHEMBL161784 | — | — | 1 | 5.34 |
| CHEMBL149175 | — | — | 1 | 5.26 |
| CHEMBL146268 | — | — | 1 | 5.22 |
| CHEMBL164268 | — | — | 1 | 5.21 |
| CHEMBL159887 | — | — | 1 | 5.15 |
| CHEMBL161374 | — | — | 1 | 5.09 |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | 5.05 |
| CHEMBL348741 | — | — | 1 | 5.04 |
| CHEMBL353576 | — | — | 1 | 5.00 |
| CHEMBL159809 | — | — | 1 | 5.00 |
| CHEMBL161012 | — | — | 1 | 4.96 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 4.96 |
| CHEMBL349619 | — | — | 1 | 4.82 |
| CHEMBL162017 | — | — | 1 | 4.80 |
| CHEMBL159685 | — | — | 1 | 4.80 |
| CHEMBL159599 | — | — | 1 | 4.77 |
| CHEMBL348361 | — | — | 1 | 4.75 |
| CHEMBL163103 | — | — | 1 | 4.68 |
| CHEMBL346689 | — | — | 1 | 4.64 |
| CHEMBL159393 | — | — | 1 | 4.58 |
| CHEMBL349708 | — | — | 1 | 4.52 |
| CHEMBL163183 | — | — | 1 | 4.27 |
| CHEMBL159946 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356033 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL358165 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL357489 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL159697 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL148690 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL146303 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL160114 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL161784 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL149175 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL146268 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL164268 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL159887 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL161374 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL513 | CARMUSTINE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL348741 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL353576 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL159809 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL161012 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL349619 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL159685 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL162017 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL159599 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL348361 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL163103 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL346689 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL159393 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL349708 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL163183 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL159946 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL159826 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL161329 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL159544 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL159395 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL160067 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL163926 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL163921 | — | IC50 | = | 198000.0 | nM | - |
| CHEMBL348908 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL347816 | — | IC50 | = | 142000.0 | nM | - |