Assay Detail
Binding
CHEMBL701990
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Inhibition of in vitro enzyme activity measured in a highly purified maize Histone deacetylase 1 preparation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.31 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320038 | — | — | 1 | 7.60 |
| CHEMBL113095 | — | — | 1 | 7.40 |
| CHEMBL110906 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320038 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL113095 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL110906 | — | IC50 | = | 120.0 | nM | 6.92 |