Assay Detail
Binding
CHEMBL701992
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Inhibition against partially purified human histone deacetylase 1 (HDAC-1)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99456 | — | — | 1 | 8.70 |
| CHEMBL95552 | — | — | 1 | 8.40 |
| CHEMBL99216 | — | — | 1 | 8.35 |
| CHEMBL95313 | — | — | 1 | 8.30 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.30 |
| CHEMBL95273 | — | — | 1 | 8.30 |
| CHEMBL451182 | — | — | 1 | 8.22 |
| CHEMBL95535 | — | — | 1 | 8.10 |
| CHEMBL96984 | — | — | 1 | 8.07 |
| CHEMBL99877 | — | — | 1 | 8.02 |
| CHEMBL95835 | — | — | 1 | 7.82 |
| CHEMBL95747 | — | — | 1 | 7.60 |
| CHEMBL319738 | — | — | 1 | 7.46 |
| CHEMBL320909 | — | — | 1 | 7.46 |
| CHEMBL95241 | — | — | 1 | 7.35 |
| CHEMBL319070 | — | — | 1 | 7.35 |
| CHEMBL99394 | — | — | 1 | 7.30 |
| CHEMBL95959 | — | — | 1 | 7.19 |
| CHEMBL95885 | — | — | 1 | 7.02 |
| CHEMBL99810 | — | — | 1 | 6.87 |
| CHEMBL98911 | — | — | 1 | 6.82 |
| CHEMBL95842 | — | — | 1 | 6.70 |
| CHEMBL95990 | — | — | 1 | 6.35 |
| CHEMBL95916 | — | — | 1 | 6.30 |
| CHEMBL95510 | — | — | 1 | 6.22 |
| CHEMBL95152 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99456 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL95552 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL99216 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL95313 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL95273 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL451182 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL95535 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL96984 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL99877 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL95835 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL95747 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL319738 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL320909 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL95241 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL319070 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL99394 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL95959 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL95885 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL99810 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL98911 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL95842 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL95990 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL95916 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL95510 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL95152 | — | IC50 | = | 1500.0 | nM | 5.82 |