Assay Detail
Binding
CHEMBL702010
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Binding affinity towards rat liver membrane, measured using equilibrium competition binding with [3H]Inositol(1,4,5)P3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bicyclic analogues of D-myo-inositol 1,4,5-trisphosphate related to adenophostin A: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.96 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | — | 1 | 9.26 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 8.34 |
| CHEMBL2092836 | — | — | 1 | 7.21 |
| CHEMBL2092858 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | Kd | = | 0.55 | nM | 9.26 |
| CHEMBL279107 | INS(1,4,5)P3 | Kd | = | 4.56 | nM | 8.34 |
| CHEMBL2092836 | — | Kd | = | 62.0 | nM | 7.21 |
| CHEMBL2092858 | — | Kd | = | 98.0 | nM | 7.01 |