Assay Detail
Functional
CHEMBL702016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Ionotropic glutamate receptor AMPA induced LDH release in cultured rat cortical neurons after 24 hr 100 uM AMPA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.13 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293206 | — | — | 1 | 5.60 |
| CHEMBL222519 | NBQX | — | 1 | 5.52 |
| CHEMBL331547 | — | — | 1 | 5.30 |
| CHEMBL122054 | — | — | 1 | 5.22 |
| CHEMBL121771 | — | — | 1 | 5.22 |
| CHEMBL432224 | — | — | 1 | 5.10 |
| CHEMBL122313 | — | — | 1 | 4.82 |
| CHEMBL333463 | — | — | 1 | 4.75 |
| CHEMBL122082 | — | — | 1 | 4.60 |
| CHEMBL125484 | — | — | 1 | - |
| CHEMBL121886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293206 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL222519 | NBQX | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL331547 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL122054 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL121771 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL432224 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL122313 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL333463 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL122082 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL125484 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL121886 | — | IC50 | > | 30000.0 | nM | - |