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Assay Detail

CHEMBL702121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Cytotoxic alpha-bromoacrylic derivatives of low molecular weight.
Beria I, Caldarelli M, Geroni C, Mongelli N, Reinach B, Vignati L, Cozzi P.
Bioorg Med Chem Lett (2002) 12 : 1467 -1471
PubMed 12031321 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.32 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL537929 1 8.74
CHEMBL556373 1 8.42
CHEMBL556031 1 8.20
CHEMBL555337 1 7.57
CHEMBL286805 1 7.43
CHEMBL36366 1 7.37
CHEMBL33590 1 7.29
CHEMBL544940 1 7.27
CHEMBL36557 1 7.23
CHEMBL544442 1 7.10
CHEMBL543738 1 7.01
CHEMBL542800 1 5.89
CHEMBL554387 1 5.70
CHEMBL543287 1 -
CHEMBL542318 1 -
CHEMBL545614 1 -
CHEMBL286462 1 -
CHEMBL554466 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL537929 IC50 = 1.8 nM 8.74
CHEMBL556373 IC50 = 3.8 nM 8.42
CHEMBL556031 IC50 = 6.3 nM 8.20
CHEMBL555337 IC50 = 27.0 nM 7.57
CHEMBL286805 IC50 = 36.8 nM 7.43
CHEMBL36366 IC50 = 43.0 nM 7.37
CHEMBL33590 IC50 = 51.9 nM 7.29
CHEMBL544940 IC50 = 54.0 nM 7.27
CHEMBL36557 IC50 = 58.6 nM 7.23
CHEMBL544442 IC50 = 79.6 nM 7.10
CHEMBL543738 IC50 = 96.8 nM 7.01
CHEMBL542800 IC50 = 1300.0 nM 5.89
CHEMBL554387 IC50 = 2000.0 nM 5.70
CHEMBL543287 IC50 > 500.0 nM -
CHEMBL542318 IC50 > 800.0 nM -
CHEMBL545614 IC50 > 2500.0 nM -
CHEMBL286462 IC50 > 5000.0 nM -
CHEMBL554466 IC50 > 5000.0 nM -