Assay Detail
Functional
CHEMBL702122
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In vitro cytotoxicity against L1210 murine lymphocytic leukemia cell lines
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.33 | 4.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339374 | — | — | 1 | 4.49 |
| CHEMBL133987 | TRIMELAMOL | — | 1 | 4.48 |
| CHEMBL135064 | — | — | 1 | 4.32 |
| CHEMBL334725 | — | — | 1 | 4.26 |
| CHEMBL336275 | — | — | 1 | 4.08 |
| CHEMBL134815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339374 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL133987 | TRIMELAMOL | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL135064 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL334725 | — | IC50 | = | 55100.0 | nM | 4.26 |
| CHEMBL336275 | — | IC50 | = | 83200.0 | nM | 4.08 |
| CHEMBL134815 | — | IC50 | = | 112500.0 | nM | - |