Assay Detail
Functional
CHEMBL702125
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In vitro cytotoxicity against L1210 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.43 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 1 | 11.00 |
| CHEMBL356103 | — | — | 1 | 10.40 |
| CHEMBL359418 | — | — | 1 | 10.30 |
| CHEMBL146774 | — | — | 1 | 10.00 |
| CHEMBL343467 | — | — | 1 | - |
| CHEMBL424112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL356103 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL359418 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL146774 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL343467 | — | IC50 | = | 0.005 | nM | - |
| CHEMBL424112 | — | IC50 | = | 0.003 | nM | - |