Assay Detail
Functional
CHEMBL702132
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Inhibition of cell growth of L1210 mouse Leukemia cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.19 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603508 | — | — | 1 | 6.52 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.52 |
| CHEMBL1130 | DOXIFLURIDINE | 3.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603508 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1130 | DOXIFLURIDINE | IC50 | = | 3000.0 | nM | 5.52 |