Assay Detail
Functional
CHEMBL702133
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Inhibition of cellular growth against mouse (L1210) deficient in thymidine kinase.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of enzyme inhibitors using iterative protein crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.81 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.23 |
| CHEMBL299928 | — | — | 1 | 6.52 |
| CHEMBL275685 | — | — | 1 | 6.42 |
| CHEMBL417222 | — | — | 1 | 6.00 |
| CHEMBL291548 | — | — | 1 | 5.70 |
| CHEMBL301256 | — | — | 1 | 5.70 |
| CHEMBL56662 | — | — | 1 | 5.69 |
| CHEMBL57002 | — | — | 1 | 5.64 |
| CHEMBL422395 | — | — | 1 | 5.46 |
| CHEMBL301844 | — | — | 1 | 5.38 |
| CHEMBL56992 | — | — | 1 | 5.22 |
| CHEMBL353700 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL299928 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL275685 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL417222 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL291548 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL301256 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL56662 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL57002 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL422395 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL301844 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL56992 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL353700 | — | IC50 | = | 20000.0 | nM | 4.70 |