Assay Detail
Functional
CHEMBL702134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.43 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320775 | NOLATREXED | 3.0 | 1 | 6.00 |
| CHEMBL166369 | — | — | 1 | 5.98 |
| CHEMBL162145 | — | — | 1 | 5.89 |
| CHEMBL349723 | — | — | 1 | 5.80 |
| CHEMBL351885 | — | — | 1 | 5.75 |
| CHEMBL423282 | — | — | 1 | 5.75 |
| CHEMBL351606 | — | — | 1 | 5.75 |
| CHEMBL166027 | — | — | 1 | 5.60 |
| CHEMBL162613 | — | — | 1 | 5.52 |
| CHEMBL163411 | — | — | 1 | 5.51 |
| CHEMBL351403 | — | — | 1 | 5.46 |
| CHEMBL349969 | — | — | 1 | 5.39 |
| CHEMBL350130 | — | — | 1 | 5.38 |
| CHEMBL164624 | — | — | 1 | 5.10 |
| CHEMBL163410 | — | — | 1 | 5.09 |
| CHEMBL163096 | — | — | 1 | 4.85 |
| CHEMBL164289 | — | — | 1 | 4.68 |
| CHEMBL165453 | — | — | 1 | 4.30 |
| CHEMBL351839 | — | — | 1 | - |
| CHEMBL351840 | — | — | 1 | - |
| CHEMBL162498 | — | — | 1 | - |
| CHEMBL164569 | — | — | 1 | - |
| CHEMBL165683 | — | — | 1 | - |
| CHEMBL163535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320775 | NOLATREXED | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL166369 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL162145 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL349723 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL351885 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL423282 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL351606 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL166027 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL162613 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL163411 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL351403 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL349969 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL350130 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL164624 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL163410 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL163096 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL164289 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL165453 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL351839 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL351840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL162498 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL164569 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL165683 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL163535 | — | IC50 | > | 4200.0 | nM | - |