Assay Detail
Functional
CHEMBL702199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against taxol resistant cell line (KBs5) at a concentration of 50 nM using tetrazolium dye reduction assay (MTT)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.87 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.15 |
| CHEMBL9011 | — | — | 1 | 7.59 |
| CHEMBL9309 | — | — | 1 | 7.46 |
| CHEMBL8953 | — | — | 1 | 7.15 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 6.74 |
| CHEMBL8939 | — | — | 1 | 5.64 |
| CHEMBL9241 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL9011 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL9309 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL8953 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 183.8 | nM | 6.74 |
| CHEMBL8939 | — | IC50 | = | 2293.2 | nM | 5.64 |
| CHEMBL9241 | — | IC50 | = | 4550.8 | nM | 5.34 |