Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL702409

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Evaluation for cytotoxicity to human tumor cell lines.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Tumor Cell line
Confidence 1 — Organism
Curated By Expert

Target

Tumor Cell line (CHEMBL613974)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic activities of Mannich bases of chalcones and related compounds.
Dimmock JR, Kandepu NM, Hetherington M, Quail JW, Pugazhenthi U, Sudom AM, Chamankhah M, Rose P, Pass E, Allen TM, Halleran S, Szydlowski J, Mutus B, Tannous M, Manavathu EK, Myers TG, De Clercq E, Balzarini J.
J Med Chem (1998) 41 : 1014 -1026
PubMed 9544201 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.90 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL555363 1 5.63
CHEMBL545358 1 5.51
CHEMBL557383 1 5.33
CHEMBL557588 1 5.23
CHEMBL545127 1 5.20
CHEMBL7976 CHALCONE 1 5.08
CHEMBL555176 1 5.05
CHEMBL552815 1 5.04
CHEMBL542780 1 5.02
CHEMBL545593 1 5.00
CHEMBL542045 1 4.84
CHEMBL545130 1 4.75
CHEMBL544894 1 4.70
CHEMBL537255 1 4.66
CHEMBL852 MELPHALAN 4.0 1 4.58
CHEMBL544893 1 4.57
CHEMBL537011 1 4.53
CHEMBL545595 1 4.40
CHEMBL440640 1 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL555363 IC50 = 2350.0 nM 5.63
CHEMBL545358 IC50 = 3090.0 nM 5.51
CHEMBL557383 IC50 = 4680.0 nM 5.33
CHEMBL557588 IC50 = 5880.0 nM 5.23
CHEMBL545127 IC50 = 6310.0 nM 5.20
CHEMBL7976 CHALCONE IC50 = 8320.0 nM 5.08
CHEMBL555176 IC50 = 8910.0 nM 5.05
CHEMBL552815 IC50 = 9120.0 nM 5.04
CHEMBL542780 IC50 = 9550.0 nM 5.02
CHEMBL545593 IC50 = 10000.0 nM 5.00
CHEMBL542045 IC50 = 14500.0 nM 4.84
CHEMBL545130 IC50 = 17800.0 nM 4.75
CHEMBL544894 IC50 = 20000.0 nM 4.70
CHEMBL537255 IC50 = 21900.0 nM 4.66
CHEMBL852 MELPHALAN IC50 = 26300.0 nM 4.58
CHEMBL544893 IC50 = 26900.0 nM 4.57
CHEMBL537011 IC50 = 29500.0 nM 4.53
CHEMBL545595 IC50 = 39800.0 nM 4.40
CHEMBL440640 IC50 = 93300.0 nM 4.03