Assay Detail
Binding
CHEMBL702428
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Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.79 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232801 | AMITROLE | — | 1 | 6.77 |
| CHEMBL130911 | — | — | 1 | 6.70 |
| CHEMBL340775 | — | — | 1 | 6.70 |
| CHEMBL419981 | — | — | 1 | 6.70 |
| CHEMBL129073 | — | — | 1 | 6.22 |
| CHEMBL129964 | — | — | 1 | 6.16 |
| CHEMBL339815 | — | — | 1 | 6.10 |
| CHEMBL129148 | — | — | 1 | 6.05 |
| CHEMBL276080 | — | — | 1 | 6.00 |
| CHEMBL341135 | — | — | 1 | 5.89 |
| CHEMBL129510 | — | — | 1 | 5.64 |
| CHEMBL83598 | — | — | 1 | 5.52 |
| CHEMBL128000 | BUTEIN | — | 1 | 4.70 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.52 |
| CHEMBL340202 | — | — | 1 | 4.52 |
| CHEMBL128729 | — | — | 1 | 4.43 |
| CHEMBL129913 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | - |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | - |
| CHEMBL423698 | — | — | 1 | - |
| CHEMBL127028 | — | — | 1 | - |
| CHEMBL129134 | — | — | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232801 | AMITROLE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL130911 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL340775 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL419981 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL129073 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL129964 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL339815 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL129148 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL276080 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL341135 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL129510 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL83598 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL128000 | BUTEIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL140 | CURCUMIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL340202 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL128729 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL129913 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL17205 | CYCLOVALONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL423698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127028 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129134 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44657 | ETOPOSIDE | IC50 | > | 100000.0 | nM | - |