Assay Detail
Binding
CHEMBL702429
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Inhibitory activity against HIV-1 integrase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.50 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418300 | — | — | 1 | 5.27 |
| CHEMBL444478 | ACETOSIDE | 2.0 | 1 | 5.11 |
| CHEMBL282731 | CICHORIC ACID | — | 1 | 4.60 |
| CHEMBL300032 | — | — | 1 | 4.54 |
| CHEMBL299686 | — | — | 1 | 4.52 |
| CHEMBL54536 | — | — | 1 | 4.50 |
| CHEMBL293573 | — | — | 1 | 4.46 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.24 |
| CHEMBL59321 | — | — | 1 | 4.16 |
| CHEMBL301656 | — | — | 1 | 4.08 |
| CHEMBL55888 | — | — | 1 | 4.05 |
| CHEMBL292137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418300 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL444478 | ACETOSIDE | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL282731 | CICHORIC ACID | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL300032 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL299686 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL54536 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL293573 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL140 | CURCUMIN | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL59321 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL301656 | — | IC50 | = | 82400.0 | nM | 4.08 |
| CHEMBL55888 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL292137 | — | IC50 | > | 118700.0 | nM | - |