Assay Detail
Functional
CHEMBL702593
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Cytotoxic activity against L-1210 parental cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (1565) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of an antitumor prodrug released by the reaction with sulfhydryl compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.63 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1563 | DAUNORUBICIN HYDROCHLORIDE | 4.0 | 1 | 7.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL157964 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1563 | DAUNORUBICIN HYDROCHLORIDE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL157964 | — | IC50 | = | 38.0 | nM | 7.42 |