Assay Detail
Functional
CHEMBL702645
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Concentration required to inhibit the growth of paclitaxel-sensitive human epidermoid carcinoma cells KB-31 by 50 percent (72 hr exposure)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of highly potent analogues of epothilones B and D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.40 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373443 | — | — | 1 | 9.96 |
| CHEMBL92925 | — | — | 1 | 9.89 |
| CHEMBL96115 | — | — | 1 | 9.89 |
| CHEMBL328208 | — | — | 1 | 9.85 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.72 |
| CHEMBL95328 | — | — | 1 | 9.68 |
| CHEMBL94599 | — | — | 1 | 9.52 |
| CHEMBL92285 | — | — | 1 | 9.35 |
| CHEMBL93904 | — | — | 1 | 9.34 |
| CHEMBL328224 | — | — | 1 | 9.23 |
| CHEMBL329993 | EPOTHILONE A | — | 1 | 8.67 |
| CHEMBL96172 | EPOTHILONE D | 2.0 | 1 | 8.57 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373443 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL92925 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL96115 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL328208 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL95328 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL94599 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL92285 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL93904 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL328224 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 2.15 | nM | 8.67 |
| CHEMBL96172 | EPOTHILONE D | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.92 | nM | 8.54 |