Assay Detail
Functional
CHEMBL702743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against L1210 mouse leukemia tumor cell line.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.43 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.75 |
| CHEMBL301311 | — | — | 1 | 6.36 |
| CHEMBL169169 | — | — | 1 | 5.85 |
| CHEMBL355355 | — | — | 1 | 5.78 |
| CHEMBL354031 | — | — | 1 | 5.77 |
| CHEMBL167656 | — | — | 1 | 5.56 |
| CHEMBL355004 | — | — | 1 | 5.47 |
| CHEMBL355556 | — | — | 1 | 5.40 |
| CHEMBL166487 | — | — | 1 | 5.30 |
| CHEMBL354150 | — | — | 1 | 5.29 |
| CHEMBL167864 | — | — | 1 | 5.22 |
| CHEMBL432949 | — | — | 1 | 5.20 |
| CHEMBL166173 | — | — | 1 | 5.16 |
| CHEMBL168888 | — | — | 1 | 5.03 |
| CHEMBL352383 | — | — | 1 | 4.87 |
| CHEMBL353585 | — | — | 1 | 4.65 |
| CHEMBL352630 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL301311 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL169169 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL355355 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL354031 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL167656 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL355004 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL355556 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL166487 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL354150 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL167864 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL432949 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL166173 | — | IC50 | = | 6870.0 | nM | 5.16 |
| CHEMBL168888 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL352383 | — | IC50 | = | 13610.0 | nM | 4.87 |
| CHEMBL353585 | — | IC50 | = | 22190.0 | nM | 4.65 |
| CHEMBL352630 | — | IC50 | = | 24540.0 | nM | 4.61 |