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Assay Detail

CHEMBL702744

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against L1210 tumor cell lines in mice
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and antitumor activity of 7-substituted 20(RS)-camptothecin analogues
Jew S, Kim H, Kim MG, Roh E, Cho Y, Kim J, Cha K, Lee K, Han H, Choi J, Lee H
Bioorg Med Chem Lett (1996) 6 : 845 -848
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.79 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50835 1 6.89
CHEMBL65 CAMPTOTHECIN -1.0 1 6.75
CHEMBL170937 1 6.19
CHEMBL424549 1 6.16
CHEMBL169372 1 5.96
CHEMBL353644 1 5.89
CHEMBL168215 1 5.54
CHEMBL355569 1 5.45
CHEMBL352762 1 5.39
CHEMBL355166 1 5.36
CHEMBL168489 1 5.04
CHEMBL353435 1 4.88
CHEMBL355582 1 -
CHEMBL168896 1 -
CHEMBL352557 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50835 IC50 = 130.0 nM 6.89
CHEMBL65 CAMPTOTHECIN IC50 = 180.0 nM 6.75
CHEMBL170937 IC50 = 640.0 nM 6.19
CHEMBL424549 IC50 = 700.0 nM 6.16
CHEMBL169372 IC50 = 1090.0 nM 5.96
CHEMBL353644 IC50 = 1290.0 nM 5.89
CHEMBL168215 IC50 = 2900.0 nM 5.54
CHEMBL355569 IC50 = 3520.0 nM 5.45
CHEMBL352762 IC50 = 4030.0 nM 5.39
CHEMBL355166 IC50 = 4360.0 nM 5.36
CHEMBL168489 IC50 = 9080.0 nM 5.04
CHEMBL353435 IC50 = 13030.0 nM 4.88
CHEMBL355582 IC50 > 100000.0 nM -
CHEMBL168896 IC50 > 100000.0 nM -
CHEMBL352557 IC50 > 100000.0 nM -