Assay Detail
Functional
CHEMBL702746
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Compound was evaluated for in vitro antiproliferative activity against L1210 mouse leukemia cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.95 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276820 | — | — | 1 | 7.46 |
| CHEMBL301393 | — | — | 1 | 6.51 |
| CHEMBL301311 | — | — | 1 | 6.36 |
| CHEMBL50835 | — | — | 1 | 6.34 |
| CHEMBL50418 | — | — | 1 | 6.05 |
| CHEMBL51495 | — | — | 1 | 5.17 |
| CHEMBL300396 | — | — | 1 | 4.85 |
| CHEMBL52226 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276820 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL301393 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL301311 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL50835 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL50418 | — | IC50 | = | 898.0 | nM | 6.05 |
| CHEMBL51495 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL300396 | — | IC50 | = | 14110.0 | nM | 4.85 |
| CHEMBL52226 | — | IC50 | = | 14004.0 | nM | 4.85 |