Assay Detail
Functional
CHEMBL702749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular growth by the MTT colorimetric assay in L1210, murine leukemia cell line
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.77 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9671 | — | — | 1 | 6.75 |
| CHEMBL1744235 | — | — | 1 | 6.66 |
| CHEMBL350841 | — | — | 1 | 6.60 |
| CHEMBL349878 | — | — | 1 | 6.55 |
| CHEMBL162592 | — | — | 1 | 6.51 |
| CHEMBL275685 | — | — | 1 | 6.42 |
| CHEMBL162593 | — | — | 1 | 6.36 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 6.31 |
| CHEMBL348858 | — | — | 1 | 6.24 |
| CHEMBL161750 | — | — | 1 | 6.16 |
| CHEMBL161404 | — | — | 1 | 6.14 |
| CHEMBL159017 | — | — | 1 | 6.09 |
| CHEMBL161291 | — | — | 1 | 6.05 |
| CHEMBL161053 | — | — | 1 | 5.92 |
| CHEMBL162411 | — | — | 1 | 5.80 |
| CHEMBL1744234 | — | — | 1 | 5.75 |
| CHEMBL161083 | — | — | 1 | 5.72 |
| CHEMBL161098 | — | — | 1 | 5.72 |
| CHEMBL161173 | — | — | 1 | 5.70 |
| CHEMBL162646 | — | — | 1 | 5.70 |
| CHEMBL159050 | — | — | 1 | 5.70 |
| CHEMBL159039 | — | — | 1 | 5.68 |
| CHEMBL162587 | — | — | 1 | 5.68 |
| CHEMBL1788170 | — | — | 1 | 5.64 |
| CHEMBL351601 | — | — | 1 | 5.64 |
| CHEMBL161453 | — | — | 1 | 5.62 |
| CHEMBL157865 | — | — | 1 | 5.58 |
| CHEMBL436435 | — | — | 1 | 5.54 |
| CHEMBL422880 | — | — | 1 | 5.52 |
| CHEMBL351495 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9671 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1744235 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL350841 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL349878 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL162592 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL275685 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL162593 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL9440 | METESIND | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL348858 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL161750 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL161404 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL159017 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL161291 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL161053 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL162411 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1744234 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL161083 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL161098 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL161173 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL162646 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL159050 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL159039 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL162587 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1788170 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL351601 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL161453 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL157865 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL436435 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL422880 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL351495 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL351499 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL162539 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL301844 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL161341 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL9728 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL350840 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL159155 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL159072 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL349078 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL158281 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL161325 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161389 | — | IC50 | > | 5000.0 | nM | - |